Assuming you installed CUDA 6.5 via RPM or DEB (not runfile), and your top-level installation exists at /usr/local/cuda-6.5, the following commands should work: $ cp cusolver_patch_linux_rpmdeb_installation.tar.gz ~ $ cd /usr/local/cuda-6.5/targets/x86_64-linux $ sudo tar zxvf ~/cusolver_patch_linux_rpmdeb_installation.tar.gz This will update the cusolver libraries inside /usr/local/cuda-6.5/targets/x86_64-linux/lib and the include files inside /usr/local/cuda-6.5/targets/x86_64-linux/include